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Improving the Safety and Security of Biological Research

1. Purpose

The order aims to mitigate the risks associated with gain-of-function research on biological agents, safeguarding American public health and national security.

2. Key Actions And Directives
  • Prohibit Federal Funding:  End federal funding for dangerous gain-of-function research by foreign entities and in countries lacking adequate oversight.
  • Strengthen Oversight:  Revise oversight policies for dual-use research within 120 days to enhance accountability and monitoring.
  • Develop Governance Strategy:  Create a strategy to manage non-federally funded gain-of-function research to ensure regulatory compliance.
  • Reporting Requirements:  Institutions receiving federal funds must submit reports on compliance with gain-of-function research oversight.
3. Important Points
  • Public Health Risk:  The research poses significant risks to public health and national security, necessitating stringent oversight.
  • Federal Research Funding:  The order highlights concerns regarding U.S. federal funding in foreign nations where oversight is limited.
  • Definitions of Danger:  Clarifies what constitutes dangerous gain-of-function research, focusing on enhanced pathogenicity or transmissibility of infectious agents.
  • Accountability Measures:  Research institutions are held accountable for maintaining standards and must report on their research activities.
  • Outcomes of Concern:  Emphasizes possible outcomes of such research, including increased transmissibility and creation of pathogens previously considered eradicated.

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